Apo/Holo Pairs

anchor

Findings

• IC-225ESM3 (1.4B) performs zero-shot protein conformation generation with competitive quality across BPTI dynamics, conformation changing pairs, and intrinsically disordered proteins [eval]
• IC-227MSA-based conformation generation methods (AlphaFlow, MSA-subsampling) outperform sequence-based methods (EigenFold, STR2STR, ESMFlow) on conformation changing pair generation [eval]