Sybil

Massachusetts Institute of Technology, Massachusetts General Hospital · 2023-01-12 · image · medical · discriminative · anchor · artifact

Lung cancer risk prediction model built on a 3D ResNet-18 encoder over low-dose chest CT, trained on NLST, predicting risk up to six years ahead from a single scan.

Variants

Sybil ensemble (5 x 3D ResNet-18)

Findings

• SY-001Objects outside the patient, gown snaps and ECG electrodes, drive Sybil's risk predictions
• SY-002Sybil responds more weakly to nodules near the pleura, where adenocarcinoma tends to appear
• SY-003Sybil processes pulmonary nodules almost additively, with limited pairwise interactions

Shared mechanisms

• Feature interactionalso in Aquila-7B, CLIP / CLIP-ViT (LC), GPT-2, LLaMA, OPT
• Positional biasalso in BERT, ChatGPT, Claude 3, Claude 3.5, Falcon, Fuyu, Gemini, Gemini 1.5 / Gemini Pro 1.5, Gemma, Gemma 2, GLIDE, GPT-2, GPT-3.5 / ChatGPT-3.5, GPT-4 / ChatGPT4 / GPT-4 Code Interpreter / GPT-4 Technical Report, GPT-4.1, GPT-4o, GPT-J, InstructGPT, LLaMA, Llama 2 / Llama 2 base, Llama 3, Mistral 7B / Mistral / Mistral 3 7B / Mistral-0.2-7B / Mistral-v0.1, Mixtral, Mixtral 8x7B / Mistral 8x7B Instruct / Mixtral 46.7B / Mixtral 8x7B Instruct / Mixtral-instruct-8x7b, MPT, O1 / OpenAI-o1-preview, O3, O4-mini, PaLM 2, Phi-3, Pythia, Qwen1.5, Qwen 2, Qwen 2.5 72B Instruct, Stable Diffusion, Vicuna
• Shortcutalso in BakLLaVA, BLIP-2, Claude 3, Claude 3.5, CLIP / CLIP-ViT (LC), CLIP4Clip, CLIPBERT, DALL·E 2, DALL·E 3, DeepSeek-VL2, Eurus-RM-7B, Falcon, FLUX / FLUX1, Gemini, Gemini 1.5 / Gemini Pro 1.5, Gemma, Gemma 2, GPT-2, GPT-3 / GPT base, GPT-3.5 / ChatGPT-3.5, GPT-4 / ChatGPT4 / GPT-4 Code Interpreter / GPT-4 Technical Report, GPT-4o, GPT-J, iFlytekSpark-13B, InstructBLIP, Internlm2-Reward, InternVideo, InternVL2, LLaMA, Llama 2 / Llama 2 base, Llama 3, Llama-3-2-Vision, LLaVA, LLaVA-1.5 / LLaVA-v1.5, LLaVA-Med, LLaVA-NeXT / LLaVA 1.6, Med-Flamingo, Merlot Reserve, MiniGPT-4, Mistral 7B / Mistral / Mistral 3 7B / Mistral-0.2-7B / Mistral-v0.1, Mixtral, Mixtral 8x7B / Mistral 8x7B Instruct / Mixtral 46.7B / Mixtral 8x7B Instruct / Mixtral-instruct-8x7b, Molmo, mPLUG-2, mPLUG-Owl3, Nova Canvas, O1 / OpenAI-o1-preview, OpenCLIP, OPT, Otter, PaLM 62B, Pythia, Qwen, Qwen 2, Qwen-VL, Qwen2.5, RadFM, ResNet / ResNet-152 / ResNet-101 / ResNet-50-BN, Stable Diffusion, Swin Transformer, TerraMind, Tulu 2, UniPerceiver, UniVL, Vicuna, Video-LLaMA, VideoCLIP, VindLU, VioLET, X-CLIP